Does bovine lactoferrin prevent late-onset neonatal sepsis?
نویسندگان
چکیده
منابع مشابه
Bovine Lactoferrin Supplementation for Prevention of Late-onset Sepsis in very Low-Birth-Weight Neonates
Paolo Manzoni, MD Matteo Rinaldi, MD Silvia Cattani, MD Lorenza Pugni, MD Mario Giovanni Romeo, MD Hubert Messner, MD Ilaria Stolfi, MD Lidia Decembrino, MD Nicola Laforgia, MD Federica Vagnarelli, MD Luigi Memo, MD Linda Bordignon, MD Onofrio Sergio Saia, MD Milena Maule, PhD, MSc, BSc Elena Gallo, MD Michael Mostert, MD Cristiana Magnani, MD Michele Quercia, MD Lina Bollani, MD Roberto Pedici...
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The incidence of neonatal late-onset sepsis (LOS) is inversely related to the degree of maturity and varies geographically from 0.61% to 14.2% among hospitalised newborns. Epidemiological data on very low birth weight infants shows that the predominant pathogens of neonatal LOS are coagulase-negative staphylococci, followed by Gram-negative bacilli and fungi. Due to the difficulties in a prompt...
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ISSN: 2319-7706 Volume 4 Number 5 (2015) pp. 172-190 http://www.ijcmas.com Neonatal sepsis is a leading cause of neonatal mortality in developing countries. Identification of the etiological agents of neonatal sepsis is essential for effective treatment. Out of 106 microbial isolates recovered from blood cultures of late onset neonatal sepsis (LONS) patients, only 70 (66 %) isolates were Gram-p...
متن کاملPrevention of neonatal late-onset sepsis: a randomised controlled trial
BACKGROUND Late-onset sepsis (LOS), defined as sepsis occurring after 48 h of age causes substantial mortality and morbidity in very low birth weight infants. Risk factors for LOS include immaturity, intravascular catheters, mechanical ventilation, and prolonged parenteral nutrition (PN). Little attention has been paid to studying the effects of PN administration methods. The aim of the study w...
متن کاملBovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial.
CONTEXT Sepsis is a common and severe complication in premature neonates, particularly those with very low birth weight (VLBW) (<1500 g). Whether lactoferrin, a mammalian milk glycoprotein involved in innate immune host defenses, can reduce the incidence of sepsis is unknown. In animal models, the probiotic Lactobacillus rhamnosus GG (LGG) enhances the activity of lactoferrin but has not been s...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2019
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(18)32390-0